Regioselective Hydrothiolation of Alkynes by Sulfonyl Hydrazides Using Organic Ionic Base–Brønsted Acid

A practical and novel approach has been developed for the synthesis of vinyl sulfides by the reaction of sulfonyl hydrazides with aryl/heteroarylacetylenes using a DBU-based ionic liquid. The system offers a new sulfur source for hydrothiolation and is endowed with green credentials

Decarboxylative Thioamidation of Arylacetic and Cinnamic Acids: A New Approach to Thioamides

A new decarboxylative strategy has been developed for the synthesis of thioamides via a three-component reaction involving arylacetic or cinnamic acids, amines and elemental sulfur powder, without the need of a transition metal and an external oxidant

MnO₂ Promoted Sequential C–O and C–N Bond Formation via C–H Activation of Methylarenes: A New Approach to Amides

A novel and efficient approach for the synthesis of amides has been developed through manganese dioxide promoted nondirected C–H activation of methylarenes under mild reaction conditions employing <i>N</i>-chloroamines as effective coupling partners

Elemental Sulfur Mediated Decarboxylative Redox Cyclization Reaction of <i>o</i>‑Chloronitroarenes and Arylacetic Acids

A decarboxylative redox cyclization strategy has been developed for the synthesis of 2-substituted benzothiazoles by the reaction of <i>o</i>-chloronitroarenes and arylacetic acids in the presence of elemental sulfur/<i>N</i>-methylmorpholine under metal- and solvent-free conditions

Nickel-Mediated <i>N</i>‑Arylation with Arylboronic Acids: An Avenue to Chan–Lam Coupling

An efficient use of NiCl₂·6H₂O, for the cross-coupling of arylboronic acids with various <i>N</i>-nucleophiles, has been demonstrated. The method is practical and offers an alternative to the corresponding Cu-mediated Chan–Lam process for the construction of the C–N bond

Convenient MW-Assisted Synthesis of Unsymmetrical Sulfides Using Sulfonyl Hydrazides as Aryl Thiol Surrogate

An efficient synthesis of unsymmetrical sulfides has been achieved via the cross-coupling reaction of aryl/het-aryl/benzyl halides with stable and easily workable sulfonyl hydrazides as thiol substitutes by means of [DBU][HOAc] and CuI under microwave irradiation

Copper-Catalyzed Thiolation of Hydrazones with Sodium Sulfinates: A Straightforward Synthesis of Benzylic Thioethers

A facile and sustainable protocol for the thiolation of hydrazones with sodium sulfinates has been developed in the presence of CuBr2 and DBU in DMF to afford diverse benzylic thioethers. Control experiments reveal a radical pathway involving a thiyl radical as a key intermediate

Copper-Catalyzed Thiolation of Hydrazones with Sodium Sulfinates: A Straightforward Synthesis of Benzylic Thioethers

A facile and sustainable protocol for the thiolation of hydrazones with sodium sulfinates has been developed in the presence of CuBr2 and DBU in DMF to afford diverse benzylic thioethers. Control experiments reveal a radical pathway involving a thiyl radical as a key intermediate

Transition-Metal-Free Regiospecific Aroylation of Nitroarenes Using Ethyl Arylacetates at Room Temperature

A novel regiospecific C­(sp³)–C­(sp²) coupling between ethyl arylacetates and nitroarenes has been developed to deliver biaryl ketones in excellent yields. The protocol is metal-free, mild, and compatible with a number of functional groups on both of the reacting partners

A Direct Metal-Free Decarboxylative Sulfono Functionalization (DSF) of Cinnamic Acids to α,β-Unsaturated Phenyl Sulfones

A metal-free room temperature decarboxylative cross-coupling between cinnamic acids and arylsulfonyl hydrazides has been realized for the first time for the synthesis of (<i>E</i>)-vinyl sulfones. The scope and versatility of the reaction has been demonstrated by the regio- and stereoselective synthesis of 22 derivatives with diverse structural features